FUNG MICHAEL S. C.,SUN CECILY R. Y.,SUN BILL N. C.,Fung Michael S. C.,Sun Cecily R. Y.,Sun Bill N. C.
申请号：
SI9931073
公开号：
SI2033659T1
申请日:
1999.02.19
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab') 2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, VA 20110-2209, under Accession Number HB-12476.
