MODIFIED DOUBLE-STRANDED POLYNUCLEOTIDE

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专利权人:

DAIICHI SANKYO COMPANY; LIMITED

发明人:

KOIZUMI, MAKOTO,HIROTA, YASUHIDE

申请号：

EP10826845

公开号：

EP2495323A4

申请日:

2010.10.29

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present invention provides a double-stranded polynucleotide having a sense strand polynucleotide consisting of a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, wherein an aryl or heteroaryl compound is bound to a phosphate group at the 5-end of the antisense strand polynucleotide.

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