National University Corporation Tokyo Medical and Dental University
发明人:
YOKOTA Takanori,YOSHIOKA Kotaro
申请号：
EP17856457
公开号：
EP3521430A4
申请日:
2017.09.29
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided is a nucleic acid strand that can efficiently deliver an antisense oligonucleotide into the body, particularly a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein the first nucleic acid strand includes a base sequence that is capable of hybridizing with at least a portion of a target transcription product, and exerts an antisense effect on the target transcription product； the second nucleic acid strand includes a complementary region having a base sequence complementary to the first nucleic acid strand and at least one overhang region located on the 5' and/or 3' side of the complementary region； and the first nucleic acid strand is annealed to the complementary region in the second nucleic acid strand.
