With the macrocyclic derivatives of what treatment proliferative diseases农业专利-农业学术服务平台

发明人:: S．贝利,S．貝利,B．J．伯克,M．R．柯林斯,J．J．崔,J．G．迪尔,J．G．迪爾,R．L．霍夫曼,Q．黄,Q．黃,T．W．约翰逊,T．W．約翰遜,R．S．卡尼亚,R．S．卡尼亞,J．C．凯思,J．C．凱思,P．T．Q．莱,P．T．Q．萊,M．A．麦克蒂古,M．A．麥克蒂古,C．L．帕尔默,C．L．帕爾默,P．F．理查森,P．F．理查,S.贝利,S.貝利,B.J.伯克,M.R.柯林斯,J.J.崔,J.G.迪尔,J.G.迪爾,R.L.霍夫曼,Q.黄,Q.黃,T.W.约翰逊,T.W.約翰遜,R.S.卡尼亚,R.S.卡尼亞,J.C.凯思,J.C.凱思,P.T.Q.莱,P.T.Q.萊,M.A.麦克蒂古,M.A.麥克蒂古,C.L.帕尔默,C.L.帕爾默,P.F.理查森,P.F.理查

摘要：: The present invention relates to the compound of formula (Φ) (its herein further definition) and be related to its pharmaceutically acceptable salt, the pharmaceutical composition containing the compound and salt with and application thereof. The compound of the present invention and salt inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and available what treats or improves aberrant cell proliferation illness (such as cancer).本發明涉及式(Φ)的化合物（其在本文中進一步定義）並涉及其藥學上可接受的鹽，含有該化合物及鹽類的藥物組合物以及其用途。本發明的化合物及鹽類抑制間變性淋巴瘤酶（ALK）和/或EML4-ALK並可用於治療或改善異常細胞增殖性病症（例如癌症）。