用於作為SHP2抑制劑之新穎雜環衍生物农业专利-农业专业知识服务系统

发明人:: MA, CUNBO,马存波,馬存波,GAO, PANLIANG,高攀亮,CHU, JIE,褚杰,WU, XINPING,吴新平,吳新平,WEN, CHUNWEI,温春伟,溫春偉,KANG, DI,康迪,BAI, JINLONG,白金龙,白金龍,PEI, XIAOYAN,裴晓言,裴曉言

摘要：: This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.本發明涉及可作為SHP2抑制劑的某些新型吡嗪衍生物（如結構式I所示），以及它們的合成及其用於治療SHP2介導的病症的用途。更具體地說，本發明涉及可用作SHP2抑制劑的稠合雜環衍生物，製備此類化合物的方法以及治療SHP2介導的疾病的方法。