The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer are also described.La présente invention concerne des compositions de nanoparticules de composés de pipérazine stables en stockage. L'invention concerne également des compositions pharmaceutiques comprenant les compositions de nanoparticules qui sont utiles pour le traitement et la prévention de maladies prolifératives, notamment le cancer.