The Board of Trustees of The Leland Stanford Junior University
发明人:
MACKALL, Crystal,LYNN, Rachel,WEBER, Evan,SOTILLO, Elena
申请号：
AU2018385706
公开号：
AU2018385706A1
申请日:
2018.12.14
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides T cells that are modified (e.g., genetically and/or functionally) to maintain functionality under conditions in which unmodified T cells display exhaustion. Compositions and methods disclosed herein find use in preventing exhaustion of engineered (e.g., chimeric antigen receptor (CAR) T cells) as well as non-engineered T cells thereby enhancing T cell function (e.g., activity against cancer or infectious disease).
