Regeneron Pharmaceuticals, Inc.; Inc.;President and Fellows of Harvard College;Regeneron Pharmaceuticals
发明人:
Lai, Ka-Man Venus,Gong, Guochun,Rinn, John,Frendewey, David,Valenzuela, David M.
申请号：
AU2014305873
公开号：
AU2014305873A1
申请日:
2014.08.07
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs.
