REGENERON PHARMACEUTICALS, INC.; INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;REGENERON PHARMACEUTICALS
发明人:
LAI, KA-MAN VENUS,GONG, GUOCHUN,RINN, JOHN,FRENDEWEY, DAVID,VALENZUELA, DAVID M.
申请号：
SG11201600036Q
公开号：
SG11201600036QA
申请日:
2014.08.07
申请国别(地区):
SG
年份:
2016
代理人:
摘要：
Genetically modified non-human animals are provided that exhibit a functional lack of one or more IncRNAs. Methods and compositions for disrupting, deleting, and/or replacing IncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more IncRNAs.
