СТИДМАН Джон Грэхэм Энтони (GB),УОЛТЕР Дэрил Саймон (GB)
申请号：
RU2010129929/04
公开号：
RU2010129929A
申请日:
2008.12.17
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof:! ! where! R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkylmethyl, phenyl-X or heteroaryl, any of which may optionally be substituted with C1-6 alkyl, CF3, - O-C1-6 alkyl, CN or 1, 2 or 3 halogen atoms； ! X represents - (CR12R13) n-； ! R12 and R13 are hydrogen or C1-6 alkyl； ! n represents an integer selected from 0-2； ! R2, R3, R4, R5 and R6 independently represent hydrogen, fluoro or methyl； and! R7, R8, R9, R10 and R11 independently represent hydrogen, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, where any of the above C1-6 alkyl, C2-6 alkenyl , C2-6 alkynyl or C3-6 cycloalkyl groups may optionally be substituted with 1, 2 or 3 halogen atoms,! so that at least two of R7, R8, R9, R10 and R11 represent a group other than hydrogen, and at least one of R7 and R11 represents a group other than hydrogen. ! 2. The composition according to claim 1, where! R1 is C1-4 alkyl or C3-5 cycloalkyl； ! each of R2, R3, R4, R5 and R6 represents hydrogen； ! R7 is hydrogen, fluoro, chloro, methyl or —CF3； ! R8 is hydrogen or —CF3； ! R9 represents hydrogen, fluorine or chlorine； ! R10 is hydrogen, fluoro, chloro or —CF3； and! R11 is hydrogen, fluoro, chloro, methyl or —CF3； ! so that at least two of R7, R8, R9, R10 and R11 represent a group other than hydrogen, and at least one of R7 and R11 represents a group other than hydrogen. ! 3. The composition according to claim 2, where! R1 is methyl, ethyl, isobutyl or cyclopropyl； ! R7 represents chlorine； ! R10 represents hydrogen； and! R11 represents hydrogen. ! 4. The compound of formula (IA) or its pharmaceutics1. Фармацевтическая композиция, содержащая соединение формулы (I) или его фармацевтически приемлемую соль: ! ! где ! R1 представляет C1-4 алкил, С2-6 алкенил, С2-6 алкинил, С3-6 циклоалкил, С3-6 циклоалкилметил-, фенил-Х- или гетероарил, любой из которых мо
