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2- (azaindol-2-yl) benzimidazoles as PAD4 inhibitors
专利权人:
Глаксо Груп Лимитед (GB)
发明人:
АТКИНСОН Стивен Джон (GB),БАРКЕР Майкл Дэвид (GB),КЭМПБЕЛЛ Мэттью (GB),ДИАЛЛО Хава (GB),ДУОЛТ Климент (GB),ГАРТОН Нейл Стюарт (GB),ЛИДДЛ Джон (GB),ШЕППАРД Роберт Джон (GB),УОЛКЕР Энн Луиз (GB),ВЭЛЛАВЭ
申请号:
RU2014152456
公开号:
RU2014152456A
申请日:
2012.07.26
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The compound of formula (I): where R is hydrogen or C 1-6alkyl; R 1 is hydrogen, C 1-6 alkyl, perhalogenomethylCalkyl-O-or Salkoxy; R 1 is hydrogen, C 1-6 alkyl or CalkoxyC 1-6 alkyl; R 1 is hydrogen, C 1-6 alkyl, perhalogenomethyl C 1-6 alkyl or unsubstituted C 1-6; —R or N; B is C-R or N; D is C-R or N; provided that at least one of A, B and D is N; R is hydrogen or C1-6 alkyl; R is hydrogen or C1-6 alkyl; R represents water od, C1-6alkyl, Salkoxy or hydroxy; R1 represents hydrogen or C1-6alkyl, provided that one of R1 and R4 represents hydrogen; R2 represents hydrogen or hydroxy; R4 represents hydrogen or C1-6alkyl; or its salt. 2. A compound of formula (I) or a salt thereof according to claim 1, wherein R is hydrogen. 3. A compound of formula (I) or a salt thereof according to claim 1, wherein R is hydrogen or Calkoxy. 4. A compound of formula (I) or a salt thereof according to claim 1, wherein R 1 is C 1-6 alkyl. A compound of formula (I) or a salt thereof according to claim 1, wherein R1 is C1-6alkyl, unsubstituted CycloalkylSalkyl or perhalogenomethylSalkyl. 6. A compound of formula (I) or a salt thereof according to claim 1, wherein R 1 is hydrogen. A compound of formula (I) or a salt thereof according to claim 1, wherein R4 is hydrogen. A compound of formula (I) or a salt thereof according to claim 1, wherein R 1 is hydrogen. A compound of formula (I) or a salt thereof according to claim 1, wherein R 1 is hydrogen. A compound of formula (I) or a salt thereof according to claim 1, wherein R1 is hydrogen. A compound of formula (I) or a salt thereof selected from the list consisting of the following1. Соединение формулы (I):гдеRпредставляет собой водород или Салкил;Rпредставляет собой водород, Cалкил, пергалогенметилСалкил-O-или Салкокси;Rпредставляет собой водород, Салкил или СалкоксиСалкил;Rпредставляет собой водород, Салкил, пергалогенметилСалкил или незамещенный СциклоалкилСалкил;А представляет собой C-Rили N;В представляет собой C-Rили N;D представляет
来源网站:
中国工程科技知识中心
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