BONFANTI, JEAN-FRANCOIS,MULLER, PHILIPPE,FORTIN, JEROME MICHEL CLAUDE,DOUBLET, FREDERIC MARC MAURICE
申请号：
ES06763809
公开号：
ES2444690T3
申请日:
2006.06.20
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound with the formula ** Formula ** a salt or a stereochemically isomeric form thereof, wherein Q is C1-6 alkyl substituted with morpholinyl or thiomorpholinyl； each of Alk independently represents C1-6-diyl alkane； R1 is pyridyl substituted with 1 or 2 substituents independently selected from the group consisting of hydroxy, C1-6 alkyl, halo and C1-6 alkyloxy； R2 is hydrogen or C1-6 alkyl； R3 is hydroxy-C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, cyano-C1-6 alkyl, aminocarbonyl-C1-6 alkyl, mono- or di- (C1-6 alkyl) aminocarbonyl-C1-6 alkyl , carboxy-C 1-6 alkyl, C 1-6 alkoxycarbonyl-C 1-6 alkyl； R4 is hydrogen or C1-6 alkyl； R5 hydrogen or C1-6 alkyl； Ar is phenyl or phenyl substituted with 1 to 5 such as 1, 2, 3 or 4 substituents selected from halo, hydroxy, amino, mono- or di- (C1-6 alkyl) amino, C1-6 alkylcarbonylamino, C1 alkyl -6-sulfonylamino, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, phenyl, hydroxyC 1-6 alkyl, polyhalo-C 1-6 alkyl, aminoC 1-6 alkyl, mono- or di- (C1-6 alkyl) -amino-C1-6 alkyl, C1-6-oxy alkyl, polyhalo-C1-6-oxy alkyl, phenoxy, aminocarbonyl, mono- or di- (C1-6 alkyl) aminocarbonyl, hydroxycarbonyl, alkoxy C1-6-carbonyl, C1-6 alkylcarbonyl, aminosulfonyl, mono- and di- (C1-6 alkyl) aminosulfonyl； Het is a heterocycle selected from the group consisting of pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, benzimothylenyl, benzimothyloyl, benzimothylenyl benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthyridinyl, 1H-imidazo [4,5- b] pyridinyl, 3H-imidazo [4,5-b] pyridinyl, imidazo [1,2-a] pyridinyl and 2,3-dihydro-1, 4-dioxino [2,3-b] pyridyl.Un compuesto con la fórmula **Fórmula** una sal o una forma estereoquímicamente isomérica del mismo, en donde Q es alquilo C1-6 sustituido con morfolinilo o tiomorfolinilo； cada uno de Alk representa, independientemente, alcano C1-6-diilo； R1 es piridilo sustituido
