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COMPOSITION CONTENANT UN STYRAXLIGNOLIDE A OU SON AGLYCONE À TITRE DE PRINCIPE ACTIF POUR PRÉVENIR OU TRAITER L'ASTHME
专利权人:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
申请号:
EP11842263.3
公开号:
EP2641604B1
申请日:
2011.11.17
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention relates to a pharmaceutical composition for preventing or treating asthma, the composition containing styraxlignolide A or an aglycone thereof as an active ingredient. More particularly, styraxlignolide A compound is one separated from stems and barks of Styrax japonica, and styraxlignolide A or homoegonol, which is an aglycone of styraxlignolide A and which has improved safety, has the effect of attenuating weight loss and airway hyperresponsiveness, inhibiting the generation of reactive oxygen species in airway, inhibiting generation of IgE, TGF-²1, and IL-17 in the serum and bronchoalveolar lavage fluid, inhibiting endobronchial inflammatory cell infiltration, and inhibiting the formation of a mucous plug and subepithelial fibrosis in an asthma-induced mouse model. Therefore, styraxlignolide or homoegonol can be effectively used as the active ingredient of a pharmaceutical composition for preventing or treating bronchial asthma in which airway remodeling has progressed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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