A medical signal processing device processes an image signal received in accordance with a result of examining inside of a subject. The image signal includes pixel data groups that are data of respective pixels different from each other and received by the medical signal processing device in parallel. The medical signal processing device includes a distribution processing unit configured to generate distributed image signals by distributing the pixel data groups, and the distribution processing unit distributes the pixel data groups such that, among the pixel data groups, pieces of data at bit positions of most significant digits of the pixel data groups of pixels adjacent to each other are included in the respective distributed image signals different from each other. The distributed image signals are transmitted to an external medical control device through respective signal transmission paths.