Schwarz, Hans-Peter,Reipert, Birgit Maria,Ehrlich, Hartmut,Kuery, Patrick,Tzekova, Nevena,Hartung, Hans-Peter,Hermann, Corinna,Bunk, Sebastian
申请号：
AU2018200026
公开号：
AU2018200026B2
申请日:
2018.01.02
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2018200026B220191205.pdf#####IgG STIMULATED REMYELINATION OF PERIPHERAL NERVES ABSTRACT OF THE DISCLOSURE [00225] The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.
