Baxter International Inc.;Heinrich-Heine-Universitat;Baxter Healthcare SA
发明人:
Patrick Küry,Nevena Tzekova,Hans-Peter Hartung,Corinna Hermann,Birgit Maria Reipert,Hans-Peter Schwarz,Hartmut Ehrlich,Sebastian Bunk
申请号：
US13781283
公开号：
US20130224150A1
申请日:
2013.02.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.
