The present invention discloses an immunotherapeutic method for treating apatient suffering from a disseminated cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or moremetastasis-draining lymph nodes (metinel nodes) draining a metastasis. Themethod comprises identification of one or more metinel lymph nodes in apatient, resection of the one or more nodes and, optionally all or part of themetastases, isolation of metastasis-reactive T-lymphocytes from said lymphnodes, in vitro expansion of said metastasis-reactive T-lymphocytes, andadministration of the thus obtained T-lymphocytes to the patient, wherein theT-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
