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Bifurcated tetrahedral conjugate
专利权人:
ARROWHEAD PHARMACEUTICALS; INC.
发明人:
JEFFREY C. CARLSON,ANDREI V. BLOKHIN
申请号:
ARP160101525
公开号:
AR104754A1
申请日:
2016.05.27
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
1. Claim 1: can of tetrapeptide, including structure represented by formula compound (1),(2) And (3) in these substances, r83088 is a natural, unnatural or synthetic L-amino acid transverse chain, R 3 is a non loaded or basic hydrofluorooctane sulfonic acid transverse chain, and R 2 is a natural, unnatural or synthetic L-amino acid transverse chain. Claim 6: it is composed of the following components: r8309 na-a83088-a3-a2-a1-r8310a (formula 4), wherein r83099 is the first compound, r8310 is the second compound, including ammonia water, a83408 is a natural hydrate, non natural or synthetic isomer, A3 is an l-aminocil without basic liquid load;2. A2 is a kind of L-amino acid, which is unnatural or synthetic isomerization. A1 is l-prolina, l-leucina or l-n-methalanina, and A1 is connected to r8310 through Amida alliance; Claim 27: a tetrapeptide modifier for reversibly combining the first compound with a compound containing ammonia water, using a biolatex tetrapeptide can, comprising r83099-a8308a3-a2-a1-r8311811, wherein r8309a represents the first compound, a8308es UN L-amino BICO natural; Non natural or synthetic isomer, A3 is a kind of amino acid or basic Daphnia without load, in which the hydrogen fobic index [sic],A2 is an L-amino acid, unnatural or synthetic isomer. A1 is composed of l-prolina, l-leucina, or l-n-methylpropene and r8311, which is a histamine reagent;Reivindicación 1: Un enlazante de tetrapéptidos, que comprende la estructura representada por los compuestos de fórmula (1), (2) y (3) en las cuales, R⁴ es una cadena lateral de un L-aminoácido hidrofóbico natural, isomérico no natural o sintético, R³ es una cadena lateral de un L-aminoácido hidrofílico no cargado o hidrofílico básico, y R² es una cadena lateral de un L-aminoácido hidrofóbico natural, isomérico no natural o sintético. Reivindicación 6: Una composición que comprende: R⁵-A⁴-A³-A²-A¹-R⁶ (fórmula 4) en la cual R⁵ es un primer compuesto, R⁶ es un segundo compuesto que contiene amina, A⁴ e
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