Thomas Langguth,Stefan Bracht,Michael Dittgen,Petra Huber,Dirk Schenk
申请号：
US14141697
公开号：
US09005653B2
申请日:
2013.12.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly.
