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COMPOSES UTILISES COMME INHIBITEURS DE RET
专利权人:
CANCER RESEARCH TECHNOLOGY LIMITED
发明人:
JORDAN, ALLAN,NEWTON, REBECCA,HYND, GEORGE,SUTTON, JONATHAN MARK,WASZKOWYCZ, BOHDAN
申请号:
CA3059134
公开号:
CA3059134A1
申请日:
2018.04.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity : Formula I wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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