Systems and methods for controlling motion of detectors having moving detector heads are provided. One system includes a gantry and a plurality of detector units mounted to the gantry, wherein the plurality of detector units are individually movable including translational movement and rotational movement. The system further includes a controller configured to control movement of the plurality of detector units to acquire Single Photon Emission Computed Tomography (SPECT) data, wherein the movement includes both the translational movement and the rotational movement coordinated to position the plurality of detector units adjacent to a subject.