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PEPTIDES CAPABLES DE REACTIVER DES P53 MUTANTS
专利权人:
YEDA RESEARCH & DEVELOPMENT CO. LTD.
发明人:
OREN, MOSHE,ROTTER, VARDA,TAL, PERRY
申请号:
CA2919855
公开号:
CA2919855A1
申请日:
2016.02.04
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The invention provides peptides that can reactivate p53 mutants efficientlyandspecifically, as well as methods that allow the identification, selection andisolation of suchpeptides, in a precise, cost and time effective manner. In particular, thereare provided mutantp53 reactivating peptides that can restore the native wild type p53 folding,and hence thetumor suppressor activity, to the mutant p53 protein. Such peptides are usefulfor treatingvarious conditions and diseases in which p53 is mutated.
来源网站:
中国工程科技知识中心
来源网址:
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