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Peptides capable of reactivating p53 mutants
专利权人:
Yeda Research and Development Co. Ltd.
发明人:
Oren, Moshe,Rotter, Varda,Tal, Perry
申请号:
AU2016200713
公开号:
AU2016200713A1
申请日:
2016.02.04
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2016200713A120160519.pdf#####103 ABSTRACT The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant 5 p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated. LO
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