Anders Burr,Michiel Ringkjøbing-Elema,Jannie Egeskov Holm,Per Holm,Birgitte Møllgaard,Kirsten Schultz
申请号：
US11711965
公开号：
US08535799B2
申请日:
2007.02.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A process for the preparation of a particulate material by a controlled agglomeration method, i.e. a method that enables a controlled growth in particle size. The method is especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutically and/or prophylactically active substance which has a relatively low aqueous solubility and/or which is subject to chemical decomposition. The process comprising i) spraying a first composition comprising a carrier, which has a melting point of about 5° C. or more which is present in the first composition in liquid form, on a second composition comprising a material in solid form, the second composition having a temperature of at the most a temperature corresponding to the melting point of the carrier and/or the carrier composition and ii) mixing or others means of mechanical working the second composition onto which the first composition is sprayed to obtain the particulate material.
