A histologic tissue sample support device includes a tissue support (12) formedof material that can be successfully sectioned in a microtome and is resistantto degradation from solvents and chemicals used to fix, process and stain tissue(40). A resilient cellular material (20) is coupled to the tissue support (12)and is configured to engage and retain tissue (40) in place during processingand embedding. The resilient cellular material (20) is also capable of successfulsectioning in the microtome and porous to allow infiltration of the solventsand chemicals used to fix, process and stain tissue, and of embedding material(50) used to embed the tissue (40) while the tissue (40) is retained by the resilientcellular material (20).
