CHRISTIAN GEGE,OLAF DR. KINZEL,CHRISTOPH STEENECK,GERALD DR. KLEYMANN,THOMAS HOFFMANN
申请号：
ARP130101871
公开号：
AR091193A1
申请日:
2013.05.29
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: compounds represented by formulas (1) to (5),an enantiomer, diastereomer, tautomer, N-oxide, solvate, formulation and pharmaceutically acceptable salts thereof, wherein R¹ is independently selected from C₁₋₁₀ alkyl,alquenilo Calquinilo CC₃₋₁₀ cycloalkyl,e. Straight ring twelveC₁₋₁₀-C₃₋₁₀ cycloalkyl alkylene,C₁₋₁₀ alkylene C₃₋₁₀ heterocycloalkyl,C₁₋₁₀- alkylene (5-membered heteroaryl),SO₂-C₁₋₁₀ alkyl,There are no substitutes, CN, or1, or 1 to 7 independent oxos,O-alkylene C₂₋₆-OR¹¹,1. Lease land No. c833218331 and 832626；halo-C₁₋₆ alkyl,Halogen, co8322； R1,UnderstandingCONR¹¹SO₂R¹¹,Cor1,SOˣR¹¹,SO₃H, SO₂NR¹¹R¹²,Number 1NR¹¹SO₂R¹¹,NR¹¹-CO-NR¹¹R¹²,NR¹¹-SO₂-NR¹¹R¹²,C₃₋₁₀ cycloalkyl,C₃₋₁₀ O-cycloalkyl,e. Straight ring twelveO-heterosexual；R 2 is R 1 or h； or R 1 and R 2. When they are taken away together with the attached nitrogen, a ring consisting of 3 to 8 members containing carbon atoms is completed, optionally containing 1 to 2 heteroatoms selected from O, s or n, Where the ring has not been replaced or replaced by 1-4 independent halogen, oxo, CN, or1 substitutes,SOˣR¹¹,SO H NR SO RSO₂NR¹¹R¹²,1. Lessor c8320316c832626-co83222； (R1),UnderstandingCONR¹¹SO₂R¹¹,Cor1,-CO-R1,NR¹¹-CO-NR¹¹R¹²,NR¹¹-SO₂-NR¹¹R¹²,Number 11. Lease land No. c833218331 and 832626；halo-C₁₋₆ alkyl,hydroxy-C₁₋₈ alkyl,C₃₋₈ cycloalkyl,C₃₋₈ O-cycloalkyl,e. Direct loop electric shock；a. Cyclopropylpropyl and acylpropylpropyl are non substituted or replaced by one or four independently selected halogen substitutes, tar c83315323；halo-C₁₋₃ alkyl,OH, O-C₁₋₃ alkyl,O-halo-C₁₋₃ alkyl,SO₂-C₁₋₃ alkyl,COOH and oxo； R3 is a single head arilo, or a double ring arilo with 6-10 members, or a single head alien,b. In this group, arilo and heteroatom can be replaced by one to five independently selected halogen and c83218c-31832626 substitutes；C₂₋₆ alkenyl,C₁₋₆ alkynyl halo-C₁₋₆ alkyl,OH, O-C₁₋₆ alkyl,O-halo-C₁₋₆ alkyl,C₀₋₆-C₃₋₁₀ cycloalkyl alkylene,C₁₋₆-C hetero-heterocycloalkyl alkylene,C₀₋₆- alkylene (5- or
