METHOD FOR INCREASING THE FREQUENCY OF EMBRYON IMPLANTATION IN THE MOTHER'S UTERINE OF MAMMALS, APPLICATION OF THE EFFECTIVE QUANTITY OF BETA-HALACTOSIDE-BINDING LECTINE OR ILL-BASED DERIVATIVES

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专利权人:

ИНПРЕНЬЯ БИОТЕКНОЛОЖИЯ И ДЕЗЕНВОЛВИМЕНТУ АВАНСАДУ ЛТДА-МЕ (BR);УНИВЕРСИДАДИ ДИ САН ПАУЛУ-УСП (BR)

发明人:

ДИАС БАРУФФИ Марселу (BR),ДА СИЛВА КАРВАЛЬЮ МОРАНИ Эрика (BR),РОНКОЛЕТТА Марселу (BR),АНДРАДЕ Камилло Дел Систиа (BR),КАТАЛДИ РОДРИГЕС Лилиан (BR)

申请号：

RU2013133832/15

公开号：

RU2013133832A

申请日:

2011.12.09

申请国别(地区):

RU

年份:

2015

代理人:

摘要：

1. A method of increasing the frequency of implantation of an embryo in the uterus of healthy mammals, characterized in that it includes introducing into the uterus of the mammal an effective amount of beta-galactoside-binding lectin or its derivatives before the preimplantation period. The method according to claim 1, characterized in that the amount ranging from 0.0000001 to 1.0 mg of the active form of beta-galactoside-binding lectin or its derivative is introduced per kilogram of the body weight of the mammal. The method according to claim 2, characterized in that the active form of the beta-galactoside-binding lectin or derivative is in the form of a sterile, stable, endotoxin-free, isotonic carrier and has a pH between 6.8 and 7.4.4. The method according to claim 3, characterized in that the carrier is a buffered solution. The method according to claim 4, characterized in that the buffered solution is selected from saline phosphate buffer (PBS) or physiological serum. The method according to claim 1, characterized in that the beta-galactoside-binding lectin or its derivative is selected from Galectin-1, Galectin-3, Galectin-9, Galectin-13, Galectin-15 or their derivatives. The method according to claim 1, characterized in that the beta-galactoside-binding lectin or its derivative is used in the uterus of the mammal along with seminal fluid, oocyte or embryo. The method according to claim 1, characterized in that the beta-galactoside-binding lectin or its derivatives are used in the uterus of the mammal along with seminal fluid, oocyte or embryo, both separately and simultaneously. The method according to claim 1, characterized in that the beta-galactoside-binding lectin or its derivatives are used in the uterus of the mammal along with seed1. Способ повышения частоты имплантации эмбриона в матке здоровых млекопитающих, отличающийся тем, что он включает введение в матку млекопитающего эффективного количества бета-галактозид-связывающего лектина или его производ

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