indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, method of preparation thereof, and pharmaceutical compositions containing them as active ingredients for the prevention or treatment of viral diseases.
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R&D
发明人:
CHONG KGO LEE,HAE SOO KIM,HEE CHUN JEONG,HENDRIK JAN THIBAUT,JIN SOO SHIN,JOHAN NEYTS,PIL HO KIM,SOO BONG HAN,YOUNG SIK JUNG
申请号：
BR112013032306
公开号：
BR112013032306A2
申请日:
2012.06.18
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
patent summary: "indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, method of preparation thereof, and pharmaceutical compositions containing them as active ingredients for the prevention or treatment of viral diseases". The present invention relates to indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, a method of preparation thereof, and a pharmaceutical composition containing them as an active ingredient for the prevention or treatment of viral diseases, comprising the same as: an active ingredient. Indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, eco-, polio-, and rhinoviruses as well as exhibiting low cytotoxicity, so they may be useful as an active ingredient of a composition for the prevention or treatment of viral diseases including poliomyelitis, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-to-mouth disease, vesicular disease, hepatitis a, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media.resumo patente de invenção: "derivados de indanona, sais farmaceuticamente aceitáveis ou isômeros óticos dos mesmos, método de preparação dos mesmos, e composições farmacêuticas contendo os mesmos como ingredientes ativos para prevenção ou tratamento de doenças virais". a presente invenção refere-se a derivados de indanona, sais farmaceuticamente aceitáveis ou isômeros óticos dos mesmos, um método de preparação para os mesmos, e uma composição farmacêutica contendo os mesmos como ingrediente ativo para prevenção ou tratamento de doenças virais,compreendendo o mesmo como um ingrediente ativo. os derivados de indanona tem uma excelente atividade inibidora contra o picornavírus incluindo coxsackie-, entero-, eco-, pólio-, e os rinovírus, assim como, exibindo baixa citotoxi
