heteroaryl derivative or pharmaceutically acceptable salt thereof, method of preparation thereof and pharmaceutical composition for the prevention or treatment of diseases associated with py3 kinases containing same as active ingredient
GE HYEONG LEE,HEE-JONG LIM,HEEYEONG CHO,JUNG HWAN CHOI,SEONG HWAN KIM,WOO KYU PARK
申请号：
BR112017025518
公开号：
BR112017025518A2
申请日:
2016.06.01
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a method of preparation thereof and a pharmaceutical composition for the prevention or treatment of diseases associated with pyinases containing it as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting pi3 kinases, thus being useful in preventing or treating pi3 kinase-related diseases such as cancers such as hematologic malignancy, ovarian cancer uterine cervical cancer, breast cancer, colorectal cancer, liver cancer, gastric cancer, pancreatic cancer, colon cancer, peritoneal metastatic cancer, skin cancer, bladder cancer, prostate cancer, lung cancer, osteosarcoma, fibrous tumors and brain tumors； autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, diabetes mellitus, hyperthyroidism, myasthenia, crohn's disease, ankylosing spondylitis, autoimmune pernicious anemia, and sjogren's syndrome； and respiratory diseases such as chronic obstructive pulmonary disease (COPD), rhinitis, asthma, chronic bronchitis, chronic inflammatory lung diseases, silicosis, pulmonary sarcoidosis, pleurisy, alveolitis, angitis, pneumatosis, pneumonia, and bronchiectasis.a presente invenção se refere a um derivado de heteroarila ou um sal farmaceuticamente aceitável do mesmo, a um método de preparação do mesmo e a uma composição farmacêutica para a prevenção ou tratamento de doenças associadas com pi3 cinases contendo o mesmo como um ingrediente ativo. o derivado de heteroarila, de acordo com a presente invenção, apresenta um excelente efeito de inibir seletivamente pi3 cinases, desse modo, sendo útil na prevenção ou tratamento de doenças relacionadas à pi3 cinase, tais como: cânceres, tais como malignidade hematológica, câncer ovariano, câncer cervical uterino, câncer de mama, câncer colorretal, câncer de fígado, câncer gástrico, câncer pancreático, câncer d
