Martin MAIER;Narayanannair K. JAYAPRAKASH;Kallanthottathil G. RAJEEV;Muthiah MANOHARAN
发明人:
Muthiah MANOHARAN,Kallanthottathil G. RAJEEV,Narayanannair K. JAYAPRAKASH,Martin MAIER
申请号：
US13326203
公开号：
US20120136042A1
申请日:
2011.12.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides iRNA agents comprising at least one subunit of the formula (I):wherein:A and B are each independently for each occurrence O, N(RN) or S；X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula (I), —P(Z′)(Z″)— or -Linker-R；R is LG, -Linker-LG, or has the structure shown below:LG is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide；RN is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl； andZ′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S.
