Muthiah Manoharan,Kallanthottathil G. Rajeev,Jayaprakash Nair,Martin Maier
申请号：
US14338161
公开号：
US09352048B2
申请日:
2014.07.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides iRNA agents comprising at least one subunit of the formula (I):wherein:A and B are each independently for each occurrence O, N(RN) or S；X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula (I), —P(Z′)(Z″)- or -Linker-R； R is LG, -Linker-LG, or has the structure shown below:LG is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide；RN is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl； andZ′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S.
