IMMUNISATION DE GRANDS MAMMIFERES A L'AIDE DE FAIBLES DOSES D'ARN

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专利权人:

NOVARTIS AG

发明人:

GEALL, ANDREW

申请号：

CA2804492

公开号：

CA2804492A1

申请日:

2011.07.06

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

RNA encoding an immunogen is delivered to a large mammal at a dose of between 2µg and 100µg. Thus the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2µg and 100µg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3ng/kg to 150ng/kg. The delivered RNA can elicit an immune response in the large mammal.

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中国工程科技知识中心

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