Immunization of large mammals with low doses of RNA

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专利权人:

GlaxoSmithKline Biologicals SA

发明人:

GEALL, Andrew

申请号：

DK11736497

公开号：

DK2591114T3

申请日:

2011.07.06

申请国别(地区):

DK

年份:

2016

代理人:

摘要：

RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding and immunogen can be delivered to a large mammal at a dose of 3 ng/kg to 150 ng/kg. The delivered RNA can elicit an immune response in the large mammal.

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