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MIA (INHIBITING MELANOUS ACTIVITY) INHIBITORS FOR IDENTIFICATION, PREVENTION AND TREATMENT OF VITILIGO
专利权人:
БОРДИНЬОН Маттео (IT)
发明人:
БОРДИНЬОН Маттео (IT)
申请号:
RU2013147195/15
公开号:
RU2013147195A
申请日:
2012.03.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The use of peptides selected from the group consisting of ID No.1 - ID No.49 for the detection, prevention and treatment of vitiligo. 2. The use of claim 1, wherein said vitiligo is non-segmented vitiligo. The use according to claim 1, where in the indicated peptides from ID No.1 to ID No.49, one or more amino acids can be replaced by a natural or unnatural amino acid. The use of claim 1, wherein said peptides from ID No.1 to ID No.49 may include an additional amino acid. The use according to claim 1, where in these peptides from ID No.1 to ID No.49, one amino acid is deleted. The use according to claim 1, where these peptides with IDs from No.1 to No.49 include at least one amino acid modified by glycosylation, acetylation, hydroxylation (hydroxyproline), carboxylation (gamma-carboxyglutamate), phosphorylation, alkylation, myristoylation ( N-terminal), palmitoylation and prenylation. 7. The use according to claim 1, where these peptides with IDs from No.1 to No.49 include at least one amino acid modified with unnatural amino acids selected from the group consisting of trans-3-methylproline, 2,4-methanoproline, cis- 4-hydroxyproline, trans-4-hydroxyproline, N-methylglycine, allo-threonine, methyltreonine, hydroxyethylcysteine, hydroxyethyl homocysteine, nitroglutamine, homo-glutamine, pipecolic acid, tert-leucine, norvaline, 2-azafenyl-alanilanilaniline and 4-fluorophenylalanine. 8. Use of an anti-MIA antibody or fragment thereof for the detection, prevention and treatment of vitiligo. 9. The use of claim 8, wherein said vitiligo is non-segmented vitiligo. The use of claim 8, where the specified anti-MIA en1. Применение пептидов, выбранных из группы, состоящей из ID No.1 - ID No.49, для выявления, профилактики и лечения витилиго.2. Применение по п.1, где указанное витилиго представляет собой несегментарное витилиго.3. Применение по п.1, где в указанных пептидах от ID No.1 до ID No.49 одна или несколько аминокислот могут быть замещены природной или неприродной ами
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