A marker delivery device (10) is configured for deploying a tissue marker. The marker delivery device includes a handle (14) having a chamber (26), and a cannula (16). The cannula (16) has a flexible portion (30) formed by a slot arrangement having of a plurality of spaced-apart substantially parallel peripheral slots (34) extending through the side wall (16-3) of the cannula to the lumen. A marker introducer rod (18) is movably disposed in the lumen of the cannula (16) for deploying the mark, and has a flexible region (50) that corresponds to the flexible portion (30) of the cannula. According to another aspect, a retraction mechanism (22) is mounted to the handle (14) and is configured to facilitate a complete retraction of both the cannula (16) and the marker introducer rod (18) into the chamber (26) of the handle upon an actuation of the retraction mechanism (22).