UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
发明人:
KAPLAN, JEFFREY B.
申请号：
CA2511103
公开号：
CA2511103C
申请日:
2003.10.31
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
Isolated nucleic acid sequences and amino acid sequences for soluble, .beta.-N-acetylglucosaminidase or active fragments or variants thereof which promotedetachment of bacterial cells from a biofilm are provided. An isolated mutantbacteria which forms biofilm colonies which tightly adhere to surface butwhich are unable to release cells into the medium or spread over the surfaceis also provided. In additions, methods are described for modulatingdetachment of bacterial cells from biofilm by mutating soluble,.beta.-N-acetylglucosaminidase or altering its expression or activity are alsoprovided. Also provided are compositions, methods and devices for preventing,inhibiting and treating bacterial infections.
