PURPOSE: A composition containing Citrus unshiu Markovich extract is provided to enhance insulin secretion and to reduce beta cell. CONSTITUTION: A pharmaceutical composition for preventing and treating type 2 diabetes contains Citrus unshiu Markovich extract as an active ingredient. The extract is a spirit extract. A health food composition for preventing and treating type 2 diabetes contains the extract as an active ingredient. The pharmaceutical composition further contains a carrier, excipient, and diluent. The daily dose of the extract is 0.0001-100 mg/kg. The pharmaceutical composition is used in the form of powder, granules, tablets, capsules, suspension, syrup, external use, and suppository.본 발명은 진피 추출물을 포함하는 2형 당료 예방 및 치료용 조성물에 관한 것으로, 본 발명에 따른 진피 추출물은 산화적 스트레스로부터 췌장 세포의 회복을 통해 인슐린 분비를 증대시키는 항산화적 방어로 2형 당뇨의 β-세포 질량의 감소와 인슐린 저항성을 개선시킬 수 있는 효과가 있다.
