The invention relates to a dermopharmaceutical or cosmetic compositioncomprising enkephalin-derived peptides for reducing and/or eliminating facialwrinkles. The inventive dermopharmaceutical or cosmetic composition is appliedto the skin, preferably the face, in order to reduce and/or eliminate facialwrinkles, preferably facial expression lines, said composition comprising adermopharmaceutically- or cosmetically-effective amount of a peptide havinggeneral formula (I). The invention also relates to the use of the peptidehaving general formula (I) in the preparation of a dermopharmaceutical orcosmetic composition used to reduce and/or eliminate facial wrinkles.