MURPHY, CHERYL A.,STOREY, JAMES,BELTZ, GERALD A.,COUGHLIN, RICHARD T.
申请号：
CA2258277
公开号：
CA2258277C
申请日:
1998.04.24
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates, in general, to granulocytic ehrlichia (GE)proteins. In particular, the present invention relates to nucleic acidmolecules coding for GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, andE46#2 proteins； purified GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, andE46#2 proteins and polypeptides； recombinant nucleic acid molecules； cellscontaining the recombinant nucleic acid molecules； antibodies having bindingaffinity specifically to GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, andE46#2 proteins and polypeptides； hybridomas containing the antibodies； nucleicacid probes for the detection of nucleic acids encoding GE S2, S7, S22, S23,C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins； a method of detecting nucleicacids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2proteins or polypeptides in a sample； kits containing nucleic acid probes orantibodies； bioassays using the nucleic acid sequence, protein or antibodiesof this invention to diagnose, assess, or prognose a mammal afflicted withehrlichiosis； therapeutic uses, specifically vaccines comprising S2, S7, S22,S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides or nucleicacids； and methods of preventing or inhibiting ehrlichiosis in an animal.
