As described herein, the combination of one or more cannabinoids with non-thermal plasma in therapeutically effective amounts synergistically improves the effects of both. A method of treating a condition of a subject using non-thermal plasma includes applying a cannabinoid vehicle comprising at least one cannabinoid topically to skin of the subject, and, using a device that generates the non-thermal plasma, applying a therapeutically effective amount of the non-thermal plasma to the subject and the cannabinoid vehicle applied to the subject. The condition may be insomnia or pain in soft tissue of the subject, and the method can include the cannabinoid vehicle onto an area of the skin near the soft tissue and operating the device to emit the non-thermal plasma at a plasma frequency of between 100 Hz and 10,000 Hz onto the area of the skin for between 20 and 40 minutes.
