A SMALL INTERFERING RNA FOR GENE KNOCKDOWN OF THE N-METHYL-D-ASPARTATE RECEPTOR NR1 SUBUNIT, ITS APPLICATION ON REDUCING THE N-METHYL-D-ASPARTATE RECEPTOR NR1 SUBUNIT IN SKIN, ITS USE AND A MEDICATION TO RELEASE SKIN INFLAMMATION PAIN
A small interfering RNA for gene knockdown of the N-methyl-D-aspartate receptor NR1 subunit, comprises 21~25 ribonucleic acids which are homologous to the RNA sequence of N-methyl-D-aspartate receptor NR1 subunit. A application of the small interfering RNA, uses the small interfering RNA to block the expression of N-methyl-D-aspartate receptor NR1 subunit in skin. A use of the small interfering RNA, with the small interfering RNA manufacture a drug for releasing skin inflammation pain. Also, a medication for treating skin inflammation pain comprises the small interfering RNA.一種抑制NMDA受體NR1之小段干擾RNA,係具有一NMDA受體次單元NR1之同源性核醣核酸序列,用以阻斷該NMDA受體次單元NR1之表現,且該小段干擾RNA為21~25個核糖核酸;一種利用小段干擾RNA抑制皮下組織NMDA受體NR1之方法,係將該小段干擾RNA,施予至一生物個體之皮下組織,以阻斷皮下組織內NMDA受體次單元NR1之表現;一種將該小段干擾RNA應用於製備用以減輕皮膚炎症性疼痛之藥物化合物以及一種減緩皮膚炎症性疼痛之藥物化合物。
