This disclosure relates to a transdermal therapeutic system (TTS) containing pramipexole or related compounds and methods of making the system as well as its use in administering such compounds as a single dose over an extended period for example one week. The system comprises an acrylic based or silicone based matrix layer containing pramipexole at concentrations of at least about 5 wt.% of the matrix which is resistant to crystallizing and discoloration of the active ingredient even when stored over long periods.
