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Transdermal administration of buprenorphine for preoperative treatment of post operative pain
专利权人:
EURO-CELTIQUE S.A.
发明人:
REIDENBERG, BRUCE E,SPYKER, DANIEL A
申请号:
NZ59415404
公开号:
NZ594154A
申请日:
2004.07.26
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Use of buprenorphine for the manufacture of a transdermal dosage form for treating postoperative pain in a patient in need of such treatment is disclosed, wherein the treatment comprises administering to said patient said buprenorphine-containing transdermal dosage form prior to surgery wherein the treatment may further comprise extended subsequent dosing periods with subsequent dosage forms for a given time period as needed by the patient to achieve desired analgesia andwherein the treatment may further comprise a rapid dose escalation of buprenorphine patches to achieve the desired preoperative dosage level, wherein the treatment involves: (a) administering to the patient a first buprenorphine-containing transdermal dosage form for a first dosing period that is no longer than 5 days (b) administering to the patient a second buprenorphine-containing transdermal dosage form for a second dosing period that is no longer than 5 days, wherein the second dosage form comprises the same dosage of buprenorphine as, or a greater dosage of buprenorphine than, the first dosage form and (c) administering to the patient a third buprenorphine-containing transdermal dosage form for a third dosing period, wherein the third dosage form comprises a greater dosage of buprenorphine than the second dosage form, and the third dosage form is the desired dosage level for the postoperative pain control.
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