This invention relates generally to methods and compositions for the treatment of nicotine addiction by administering ibogaine, an ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof to a patient in low doses. This invention further relates generally to methods and compositions for the treatment or prevention of relapse of nicotine use by administering ibogaine, an ibogaine derivative, or a pharmaceutically acceptable salt and/or solvate thereof to a patient in low doses.