Mark P. Warchol,Folke Moren,Kristina Thyresson,Elisabeth Sthengel,Sven-Borje Andersson
申请号：
US12818616
公开号：
US08642627B2
申请日:
2010.06.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided are liquid pharmaceutical formulations comprising nicotine in any form for administration essentially to the lungs being acidified and/or alkalized by buffering and/or pH regulation providing for a tmax of nicotine in arterial blood of a subject within a short period of time after administration. The administration is preferably accomplished by spraying an aerosol into the oral cavity for further distribution essentially into the lungs. Methods for manufacturing the formulation is also disclosed, as are uses of the formulation in therapy, such as therapy for treating addiction to tobacco.
