Improved oligonucleotide and pharmaceutical composition comprising the oligonucleotide

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专利权人:

国立大学法人豊橋技術科学大学

发明人:

梅影 創,越智 明徳,菊池 洋

申请号：

JP2013518196

公开号：

JP6021018B2

申请日:

2012.05.30

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The purpose of the present invention is to provide a native linear RNA molecule which can be produced in a simple manner and has nuclease resistance. The present invention provides an RNA molecule which is characterized by comprising a nucleotide sequence represented by general formula (1) or a nucleotide sequence substantially comprising the above-mentioned nucleotide sequence but having the mutation in one to several nucleotides therein, and is also characterized by having nuclease resistance capability. 5'-GGUUAGGGUUACX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16ACGAAACAAAAAAUGG-3' (1) [In formula (1), X1 to X16 independently represent any nucleotide selected from adenine, cytosine, guanine and uracil.]

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