Hartoun Hartounian,Dagmar Meissner,Clint B. Pepper
申请号：
US13791302
公开号：
US20140004173A1
申请日:
2013.03.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.
