Yuzhuo Wang,Hui Xue,Sze Ue Luk,Peter Wilhelm Gout,Martin E. Gleave,Colin C. Collins
申请号：
US15211857
公开号：
US09790500B2
申请日:
2016.07.15
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer childhood de novo acute myeloid leukemia colorectal cancer neuroblastoma melanoma and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).
