BRITTON CORKEY,GREGORY NOTTE,KEITH KOCH,LAWRENCE S. MELVIN,MICHAEL GRAUPE
申请号：
BR112012000894
公开号：
BR112012000894A2
申请日:
2010.07.12
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
