Michael Graupe;Lawrence S. Melvin, Jr.;Gregory Notte;Keith Koch;Britton Corkey
发明人:
Britton Corkey,Michael Graupe,Keith Koch,Lawrence S. Melvin, Jr.,Gregory Notte
申请号：
US13618841
公开号：
US08598360B2
申请日:
2012.09.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to compounds of Formula (I):wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
